Monday, December 22, 2014

Biochemistry of Hyperthyroidism

  Hello everyone, we're back! So today we'll be talking about the biochemistry of the hyperthyroidism. So, as you guys know, hyperthyroidism is the mass production of thyroid hormones from the thymus. But what are the common thyroid hormones that get mass produced?

1. Thyroxine (T4)
2. Tri-iodothyronine (T3)

- How are these hormones produced?

Central production : T3 & T4 formed in the cells

                             Peripheral production: Protease digest thyroglobulin to produce T3& T4

These hormones are essential for food breakdown and converting it to chemical energy for our body to function normally. However, with the increase production of these thyroid hormones, cells that normally take in a certain amount of thyroid hormones will increase their intake of thyroid hormones, thus increasing cellular activities and metabolism and causing it to speed up unlike normal cellular rate. 

Next will be telling you what are the causes of Hyperthyroidism so do stay tune to our next post!

Joanne :D

References:
http://en.wikipedia.org/wiki/Thyroid_hormone
http://www.endocrineweb.com/endocrinology/overview-thyroid
http://edusanjalbiochemist.blogspot.sg/2012/12/hyperthyroidism-causes-and-symptoms.html
http://www.endocrine.niddk.nih.gov/pubs/Hyperthyroidism/
http://www.iasj.net/iasj?func=fulltext&aId=34584

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3 comments:

  1. Mei YingDecember 23, 2014 at 8:24 AM

    What does it mean by 'central production' an 'peripheral production'?

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    Replies
    1. I don’t like carrotsDecember 25, 2014 at 8:10 PM

      Hello Meiying, for central production, it is the production of T3 and T4 hormones by the follicle cells of the thyroid glands that is being regulated by the Thyroid stimulating hormone. As for Peripheral production, it is the production of T3 & T4 hormones by converting Thyroxine, a prohormone. The enzyme that is active in peripheral production is iodothyronine deiodinase.
      Thanks for raising this question and i hope this helps to clarify your question ^^

      Delete
  2. I don’t like carrotsDecember 25, 2014 at 8:10 PM

    This comment has been removed by the author.

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